منابع مشابه
Mitotic motors
T HE complex but well-controlled motions of chromosomes during mitosis have long evoked the view that the mitotic spindle contains enzymes capable oftransducing chemical energy into mechanical work, but the nature ofthese "motor" molecules has been elusive . During the last 40 years, three ideas have dominated the field : (a) microtubules (MT)' attach to chromosomes and move them by the additio...
متن کاملMitotic Motors: Kinesin-5 Takes a Brake
A kinesin-5-dependent 'sliding filament' mechanism is commonly used to actively push apart the poles during mitotic spindle assembly and elongation, but a recent study now shows that, in C. elegans, kinesin-5 is deployed as a brake to slow down spindle-pole separation.
متن کاملPurification and assay of mitotic motors.
To understand how mitotic kinesins contribute to the assembly and function of the mitotic spindle, we need to purify these motors and analyze their biochemical and ultrastructural properties. Here we briefly review our use of microtubule (MT) affinity and biochemical fractionation to obtain information about the oligomeric state of native mitotic kinesin holoenzymes from eggs and early embryos....
متن کاملMitotic motors coregulate microtubule patterns in axons and dendrites.
Microtubules are nearly uniformly oriented in the axons of vertebrate neurons but are non-uniformly oriented in their dendrites. Studies to date suggest a scenario for establishing these microtubule patterns whereby microtubules are transported into the axon and nascent dendrites with plus-ends-leading, and then additional microtubules of the opposite orientation are transported into the develo...
متن کاملMitotic motors and chromosome segregation: the mechanism of anaphase B.
Anaphase B spindle elongation plays an important role in chromosome segregation. In the present paper, we discuss our model for anaphase B in Drosophila syncytial embryos, in which spindle elongation depends on an ip (interpolar) MT (microtubule) sliding filament mechanism generated by homotetrameric kinesin-5 motors acting in concert with poleward ipMT flux, which acts as an 'on/off' switch. S...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1991
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.115.3.577